β2-Microglobulin (β2-MG) derived amyloidosis has become a major concern in long-term hemodialysis patients. Clinical symptomatology is largely restricted to the articular and periarticular sites and in rare cases systemic manifestations have been described. We will present a long-term hemodialysis patient who developed tarsal tunnel syndrome due to a solid tumor, causing numbness and pain in his right foot and toes. Removal of the tumor and pathological examination demonstrated amyloid that was positive to β2-MG by specific antibody testing.
