Twenty-nine cases of osteosarcoma have been treated since 1982 to 1994 in Kagosima University Hospital. Chemotherapy consisted of thirteen cases receiving the Compadri V protocol, twelve were lealed with Posen T10 ot T12 and one with high dose ifosfamide. Disease free rate assouated with the Rosen T10 or T12 protocol was a little higher than that for Compadri V. Operations performed included twelve cases reguring amputation or disarticulation and fourteen limb-salvage poeratons. There was no significant difference between disease free rate of subject having amputation or disarticulation and that of limb-salvage operation. Five years surveval rate of all cases was 50.7% and that of IIb was 55.6% by Kaplan-Meier method, and five year disease free rate was 45.2%. There was no correlation between plain X-ray evaluation of sadjuvant chemotherapy and prognosis. It was suggested that high dose fosfamide chemotherapy was effective for metastic osteosarcomas.
