1997 年 46 巻 4 号 p. 1217-1219
We report a case of malignant fibrous histiocytoma occuring in the thigh of an 18 year-old female. At first, the tumor was too large to resect completely, and we therefore used preoperative adjuvant therapy comprising irradiation (Liniac; 60Gy) and multidrug chemotherapy (MAID; combination of Doxorubicin, Ifosphamide, Dacarbazine and uroprotection by MESNA). After treatment, the tumor markedly decreased in size, 60% by volume as measured by CT, and histologically 90% necrosis was confirmed. Hemipelvectomy was performed. However, the patient could not receive further adjuvant chemotherpy because of post-operative deep infection. Six months after surgery, retroperitoneal metastases wete detected, and she died of recurrent disease twelve months later.