放射性同位元素P³²を用いる大腸の吸収機能検査法に関する研究

抄録

In order to examine the absorption function of colon, the author invented the absorption-test of colon by mans of enema-method containing P³² and he obtained the following results.
1) P³² appeared into general circulating blood in about two-thirds of 26 cases within 5 minutes, and it was excreted into urine in about five-sixths of 59 cese within 30 minutes after the enema with P³².
2) The concentration of P³² in blood of normal colon-group increased gradually in the course of time until 24 hours after the enema with P³². But in the group with severe ulcerative colitis, rapid increase of P³² occurred during from about 30 minutes to 1 hour, and then the concentration increased gradually until 24 hours.
3) There were correlations between the concentration of P³² in blood and cumulative excretion-rate of P³² in urine during one, four and tweenty-four-hours period after pouring the enema with P³².
4) During the first 4-hours' period after the enema with P³², the average of the excretionrate of P³² in the group with severe ulcerative colitis was the highest value of all other cases, and there were significant differences between this disease and normal colon-group, the group with slight ulcerative colitis and the other coloic diseases except chronic non-ulcerative colitis, respectively.
But during the 24-hours' period he did not recognize the differences between this group and normal colon-group.
On the other hand, the averages of the group with cancer or tuberculosis and the group with coloptosis or elongation of sigmoid colon were both exceedingly lower than that of normal colon-group and the group with severe ulcerative colitis.
5) Next, he investigated the P³² excretion-rate in urine per an hour during the first 2 houre, from 2 to 4 hours and from 4 to 24 hours after the enema with P³².
In normal colon-group, the excretion-rate seemed to increase in the course of time until 24 hours, and in the group with mild ulcerative colitis and the group with cancer or tuberculosis of colon, the excretion-rate appeared to decrease contrary to normal colon-group. In the group with severe ulcerative colitis, however, this rate was the highest value during from 2 to 4 hours after the enema of P³² and the significant differences were recognized between this group and the other groups, then the rate decreased significantly.
In the group with coloptosis or elongation of sigmoid colon, the excretion-rate seemed to keep the low value throughout all in test.
Consequently, this absorption-test of colon is useful to distinguish the degree of ulcerative colitis and available in differential diagnosis of the severe ulcerative colitis from other diseases of colon, especially carcinoma or tuberculosis of colon.