外科的上腹部疾患におけるロイシンアミノペプチダーゼ活性変動について

抄録

Leucine aminopeptidase is a proteolytic enzyme widely distrib uted in human tissue andbody fluid. This report deals with a study of LAP which acting on L-leucyl-beta-naphthyamide.LAP activity in serum, bile and liver tissue of normal subjects and of patients withsurgical upper abdominal disorders was assayed by the method of Goldbarg et al.
The results are summarized as follows:
1) Serum LAP activity increased in hepatobiliary obstraction, especially in malignantconditions.
2) The serum LAP test was the more useful in indicator than serum AP for hepatobiliarydisease.
3) It was difficult to differenciate the causes of biliary obstruction by the level of serumLAP activity.
4) Liver tissue LAP activity increased in choledocholithiasis and malignant biliary obstruction.It was suggested that serum LAP activity in hepatobiliary disorders reflects thesealternations of tissue LAP levels.
5) LAP activity markedly decreased in white bile.
6) If the patient's liver function within normal limits, serum LAP activity increasedand liver tissues (LAP) activity decreased during the operative procedure. In icteric patientsnot only serum LAP activity was decreased but also liver tissue activity was decreased bythe relief of biliary obstruction.
7) Unfortunately, biliary obstruction was not rescured the serum LAP activity more elevatedthan before operation.
8) The measurement of LAP activity is reliable indicator for the effects of operation ofhepatobiliary tree.