兄弟に発生した潰瘍性大腸炎について

抄録

Ulcerative colitis occurring in two brothers, 25 and 16 years ofage, with an interval of approximately 5 years, is decribed. This is the first report in this country in which familial occurrence of ulcerative colitis was noted. The colon of the older brother was totally removed and found to be of typical ulcerative colitis, the changes starting from the rectum and extending to involve the entire colon; the ileum was intact showing a clear boundary between the changed cecal and the normal ileal mucosae. Such distinct confinement of the disease to the colonic mucosa strongly suggests an organ specific disease, and the distinction between the ileal and colonic mucosae. The younger brother exhibited typical but less advanced features of the disease. Steroid therapy has been unsatisfactory in both cases, although some response was noted at the beginning.
No etiological relationship has been elicited in these patients, neither was the blood type found to be of significance. It was presumed that constitutional resemblance has provided a basis on which some autoimmune process against colonic mucosa has been initiated. A critical review on familial occurrence of ulcerative colitis has been made.