ヒト肝に於ける線維タンパク代謝に関する研究

第1報 各種肝疾患に於ける肝線維タンパクの生成活性

抄録

The in vitro synthesis of the hepatic proteins, especially of collagen was examined from C¹⁴proline, using liver homogenate taken by biopsy in patients with and without liver disease.
Under certain assumptions, 13.8mg N protein are synthesized per gram liver per day, and the half-lives of hepatic proteins, were calculated to be 3.50 days for the Hot-TCA soluble fraction (Hepatic collagen), 1.45 days for the TCA insoluble fraction (Hepatic protein).
In chronic liver disease, the specific activity of the TCA soluble fraction (Free amino acid) increased.
The specific activity of the Hot-TCA soluble fraction increased in chronic active hepatitis and liver cirrhosis.
In the latter, the specific activity of the Hot-TCA insoluble fraction (non-collagen protein) was also increased.
The specific activity of the Hot-TCA soluble fraction was well correlated with serum gamma-globulin, ZST, GOT, and was inversely proportional to serum Albumin.