拘束性胃出血の発生機序に関する実験的研究
胃粘膜微小循環系の変化を中心にして
1970 年 67 巻 3 号 p. 190-200
詳細
1970 年 67 巻 3 号 p. 190-200
There are many unsolved problems on the pathogenesis of acute stress ulcer or gastric hemorrhage.
In this study the microcirculatory changes in the stomach after the restraint were investigated with biomicroscope and by the analyses of the local blood.
Gastric hemorrhages or erosions were developed in 9 of 10 wistar strain male rats after 3-hour restraint.
Biomicroscopic observation disclosed the dilatation and the increase in permeability of the microvessels in the gastric mucosa after the restraint.
The analyses of the local blood revealed several interesting changes after the restraint as follows: hemoconcentration and the decrease in serum albumin, which might be due to the increase in vascular permeability, and the increase in plasmin activity of whole blood and the fall of plasma fibrinogen level, which might be occurred after the intravascular thrombosis or the alterations of blood coagulation system.
These results suggest that the microcirculatory system in the gastric mucosa can play an important role in the pathogenesis of restraint-induced gastric hemorrhage.
