Excretion of anticancer and antimicrobial drugs into pancreatic juice

Abstract

Pancreaticj uice and bile were separatelyc ollectedb y insertinga polyethylenet ube via duodenum using rats. Immediately after intravenous administration of secretin (15 units per rat), an anticancero r antimicrobiald rug was given intravenously. Pancreaticj uice and bile were collected 1-hour's period. Serum and urine were taken after 1-hour after administration of drugs. The tissues of pancreasa nd liver wereh omogenizedin salinea fter 1-hour.
The drugsu sed and the dosesg ivenw erea s follows;M itomycin C (1.6mg per rat), Ampicillin (250mgp er rat), and Cephalothin (250mg per rat). The determinationo f activityo f each drug was made by the microbiologicaal ssay-procedure. F ive or six rats were used in experiments about each drug.
The significanht igh concentrationo f Mitomycin C was showni nurine and bile. The concentrationo f 5-Fluorouraciwl as seen in urine and blood; moderate concentrationw as shown in pancreaticj uice and bile. The high concentrationo f Neocarzinostatinw as seen in urine and pancreaticj uice. The high concentration of Cephalothinw as seeni n bile and pancreatic juice.
The concentration of ampicillin was high in blood, urine, and bile. In conclusions, relatively high excretion into pancreatic juice was demonstrated in 5-Fluorouracil, Neo carzinostatin, and Cephalothin.