THE MORPHOLOGIC CHANGES OF LANGERHANS ISLET CELLS AFTER PARTIAL HEPATECTOMY IN THE RAT

Abstract

The effects of the partial hepatectomy on Langerhans islet cells were studied by elecrtron microscope and morphological findings of B cells were estimated by morphometric analysis, in an effort to correlate biochemical date, including IRI, IRG and glucose. Empty granular sacs were increased in number and Golgi apparatus and SER were proliferated. Mitochondoria were increased in number and were globular in shape. These changes of cytoplasmic organellae in B cells were prominently observed on the 3rd day after partial hepatectomy and gradually return to normal ultrastructure by 7 days. These morphological findings seem to reflect a hyperfunction of B cells. The morphologic changes of Langerhans A cells after partial hepatectomy revealed similar findings of changes of B cells. These Results suggested that hyperfunction of Langerhans islet cells induced by partial hepatectomy was closely asociated with multiplication of hepatocytes.