INFLUENCE OF ANTRECTOMY AND H₂-RECEPTOR ANTAGONIST ON GASTRIC HYPERSECRETION ASSOCIATED WITH A SIMULTANEOUS LIGATION OF THE BILE AND PANCREATIC DUCTS IN DOGS

Abstract

In two dogs provided with Heidenhain pouch, we studied the effect of antrectomy and ingestion of H₂-receptor antagonist on acid secretion, serum secretin levels and serum gastrin levels after a test meal with a simultaneous ligation of the bile and pancreatic ducts.
Gastric hypersecretion was observed in antrectomised dogs after the ligation and abolished by ingestion of H₂-receptor antagonist. Serum secretin levels elevated after the ligation and returned to the control levels by ingestion of H₂-receptor antagonist. Serum gastrin levels were kept under 20pg/ml in these experiments. These results suggest that gastric hypersecretion induced by a simultaneous ligation of the bile and pancreatic ducts is not simply due to release of antral gastrin and hypersecretinemia may be secondary to gastric hypersecretion.