1985 Volume 82 Issue 1 Pages 28-33
Quantitative changes of gastric mucosal glycoproteins as well as macroscopical mucosal lesion induced by ethanol in rat have been studied. The mucus glycoprotein in gastric mucosa was isolated from the corpus region of the stomach excised at three and five hours after 30-100% ethanol administration.
1) Both the decrease in gastric mucus glycoproteins and the increase in macroscopical mucosal damage were related to ethanol concentration.
2) When 30-40% ethanol was administered in rats orally, the recovery of gastric mucus glycoprotein contents and from macroscopical damage was observed at five hours after dosing. However, the recovery was not observed over 50% ethanol administration.
The reduction on gastric mucus glycoproteins did not exceed about 50% of the control value, even when 70-100% ethanol was administered.
Nippon Shokakibyo Gakkai Zasshi
Nippon Shokakibyo Gakkai Zasshi Kou
