ラット胃被覆および粘膜内粘液の組織化学的研究 (第2報) Aspirin 胃粘膜障害に対する数種抗潰瘍剤の作用

鳥居 明; 穎川 一忠; 有泉 雅博; 岩崎 仁; 野沢 博; 鬼沢 信明; 川村 忠夫; 亀田 治男; 高山 昭三

doi:10.11405/nisshoshi1964.82.34

HISTOCHEMICAL EXAMINATION OF GASTRIC COVERING AND EPITHELIAL MUCUS IN RATS (THE 2ND REPORT)

Effect of Several Anti-Ulcer Drugs on Aspirin-Induced Mucosal Damage

Akira TORII, Kzutada EGAWA, Masahiro ARIIZUMI, Hitoshi IWASAKI, Hiroshi NOZAWA, Nobuaki ONIZAWA, Tadao KAWAMURA, Haruo KAMEDA, Shozo TAKAYAMA

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Akira TORII
The First Department of Internal Medicine, the Jikei University School of Medicine
Kzutada EGAWA
The First Department of Internal Medicine, the Jikei University School of Medicine
Masahiro ARIIZUMI
The First Department of Internal Medicine, the Jikei University School of Medicine
Hitoshi IWASAKI
The First Department of Internal Medicine, the Jikei University School of Medicine
Hiroshi NOZAWA
The First Department of Internal Medicine, the Jikei University School of Medicine
Nobuaki ONIZAWA
The First Department of Internal Medicine, the Jikei University School of Medicine
Tadao KAWAMURA
The First Department of Internal Medicine, the Jikei University School of Medicine
Haruo KAMEDA
The First Department of Internal Medicine, the Jikei University School of Medicine
Shozo TAKAYAMA
The Department of Experimental Pathology, Cancer Institute

Keywords: aspirin, prostaglandin E₂, pirenzepine, cimetidine

JOURNAL FREE ACCESS

1985 Volume 82 Issue 1 Pages 34-42

DOI https://doi.org/10.11405/nisshoshi1964.82.34

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Abstract

The changes of covering and epithelial mucus at the different segments of stomach with the aspirin induced mucosal damage were studied by histochemical method.
The oral administration of aspirin to rats decreased gastric covering and epithelial mucus and induced erosion with necrosis. On the contrast, in prostaglandin E₂, pirenzepine, and cimetidine treated rats before the aspirin administration, the gastric mucosal damage and the decrease of mucus were suppressed. In addition, prostaglandin E₂ and pirenzepine increased covering mucus comparing with the healthy control group.
Gastric mucus, especially covering mucus, is very important as a defensive factor to the prevention of aspirin induced mucosal damage.

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