Effect of Expression of P-glycoprotein on Technetium-99m Methoxyisobutylisonitrile Single Photon Emission Computed Tomography of Brain Tumors

Abstract

The expression of P-glycoprotein was investigated immunohistochemically in 26 brain tumor tissues and compared with the findings of technetium-99m methoxyisobutylisonitrile single photon emission computed tomography (^99mTc-MIBI SPECT) to clarify the effect of P-glycoprotein on the diagnostic accuracy. P-glycoprotein labeling index of both tumor cells and vascular endothelial cells showed no clear relationship with the findings of ^99mTc-MIBI SPECT imaging. Expression of P-glycoprotein has no effect on the diagnostic accuracy of ^99mTc-MIBI SPECT.