1976 Volume 16pt2 Issue 1 Pages 55-63
The authors investigated immediate endocrinological reactions due to various direct operations of intra and para-sellar disorders and also their long-term results.
With regards to hypofunction of the pituitary gland, the order of susceptibility of each hormone was observed as shown: GH, LH and FSH, TSH, ACTH. This order has already been accepted in common as noted in a number of publications.
Pituitary hypofunction worsened after operation when pituitary adenoma was totally removed, whereas, it improved in some cases when the tumor was partially removed by operation.
No improvement of pituitary hypofunction was observed immediately after craniopharyngioma operation. The level of every hormone, with the exception of TSH, was low in cases of craniopharyngioma.
After the operation of other parasellar tumors, pituitary hypofunction usually improved.
In case of intracranial aneurysm, especially anterior communicating artery aneurysm, various combinations of pituitary hypofunction hormones were observed prior to as well as after operation. This phenomena was attributed to the position and extent of the aneurysmal dome toward the sella turcica.
Operative stress, i.e. aneurysmal rupture in the course of direct approach or circulatory disorder of the feeding artery to the pituitary gland and hypothalamus by local dissection, may have significant ill effects on the postoperative pituitary hypofunction.
