Abstract
Postoperative outcome of intracranial meningiomas was studied with consideration to the role of intraosseous lesions on their recurrences. Overall recurrences were found in 20 out of 90 follow-up patients, and five of these meningiomas were regarded as extracranial recurrences (25% in ratio). Bone changes associated with tumorous invasion were roentgenologically revealed in all cases of extracranial recurrence. Bone scintigraphy with 99mTc-EHDP was productively utilized to detect the extent of osseous involvement. Noticably such bone changes were exhibited even at the early stage of clinical manifestation, and tumorous invasions were microscopically detected in all bone specimens taken from the site adjacent to dural attachment. It is noteworthy that intraosseous invasion of intracranial meningiomas probably occurs at relatively early stages of tumor growth and plays a possibly significant role in tumor recurrence, in particular in cases of meningiomas seated at the base of skull.
