Comparative Study of Delayed Brain Damage in Pubescent and Adult Rhesus Monkeys from Radiation within the Therapeutic Range

Shinichiro WAKISAKA; Hiroyuki NAKAGAKI; Raymond R. O'NEILL; Thomas L. KEMPER; William F. CAVENESS

doi:10.2176/nmc.22.7

Shinichiro WAKISAKA, Hiroyuki NAKAGAKI, Raymond R. O'NEILL, Thomas L. KEMPER, William F. CAVENESS

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Keywords: differential radiosensitivity with respect to age, delayed radiation damage, monkey brain

JOURNAL FREE ACCESS

1982 Volume 22 Issue 1 Pages 7-10

DOI https://doi.org/10.2176/nmc.22.7

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Abstract

The whole brains of pubescent and fully adult rhesus monkeys were subjected to 6, 000 rads of fractionated supervoltage X-irradiation, and the difference of these two age groups in clinical and neuropathological changes after the irradiation was studied. The pubescent monkey was more vulnerable to irradiation than the fully adult monkey, and showed more clinical signs and more focal lesions of delayed brain damage from radiation.

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