Abstract
Hepatoma cells from ascitic fluid were injected into peripheral nerves of rats. Involvement of the central nervous system was observed in 6 of 41 animals. Five of these 6 rats showed subarachnoid dissemination of tumor, and in 3 of these there was involvement of both the brain and spinal cord. None showed parenchymal lesions. It is concluded that diffuse leptomeningeal carcinomatosis may result from involvement of peripheral nerves by tumor.
