Abstract
A total of 52 patients with growth-hormone (GH) secreting adenoma were treated by transsphenoidal microsurgery. The procedure, as a rule, consisted of complete debridement of tumorous tissue while preserving as much normal pituitary tissue as possible. In 47 of the 52 patients (90%), the blood GH level was normalized, and the abnormal response of blood GH level to TRH and LH-RH disappeared after surgery in 25 out of 37 cases (68%). In all 16 patients with diabetes mellitus, a complete cure or improvement was observed and the five cases with bitemporal hemianopsia showed improvement of the visual acuity and the visual field.
