Hypothalamic Hamartoma associated with Precocious Puberty Case Report

Amei WANG; Yoko NAKASU; Masaharu ICHIKAWA; Satoshi NAKASU; Jyoji HANDA; Keiko OKUMURA; Noriaki OHYA

doi:10.2176/nmc.27.336

Hypothalamic Hamartoma associated with Precocious Puberty

Case Report

Amei WANG, Yoko NAKASU, Masaharu ICHIKAWA, Satoshi NAKASU, Jyoji HANDA, Keiko OKUMURA, Noriaki OHYA

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Keywords: hamartoma, hypothalamus, precocious puberty, luteinizing hormone-releasing hormone

JOURNAL FREE ACCESS

1987 Volume 27 Issue 4 Pages 336-340

DOI https://doi.org/10.2176/nmc.27.336

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Abstract

A hypothalamic hamartoma associated with true precocious puberty in a 2-year-old girl is reported. Following subtotal removal of the tumor, endocrinological abnormalities as well as clinical manifestations of precocious puberty were restored to normal. Although the immunofluorescence study of the specimen was negative, ultrastructural studies revealed dense core vesicles of approximately 100 nm in size in the neurons. The mechanisms of precocious puberty in patients with a hypothalamic hamartoma are briefly discussed.

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