Intracranial Collision Tumor composed of Ganglioglioma and Meningioma

Case Report

Abstract

A 25-year-old male with an intracranial collision tumor is presented. Plain computed tomography disclosed a low-density area in the left frontal lobe, which was markedly enhanced by contrast medium. Left carotid angiography revealed an avascular area that corresponded to the low-density area. The tumor was totally removed. Macroscopically, the tumor tissue was well demarcated and solid. Histological examination disclosed two components. One was a ganglioglioma containing large ganglion-like cells and Nissl substance (Klüver-Barrera staining). The other, a fibrous meningioma, consisted of partially calcified, spindle-shaped cells, which did not stain with glial fibrillary acidic protein. The diagnosis was collision tumor composed of ganglioglioma and fibrous meningioma. The authors could find no reports of intracranial collision tumors consisting of ganglioglioma and fibrous meningioma in the literature. The existing literature concerning intracranial collision tumors is discussed from a histopathological standpoint.