Effects of Perfluorochemicals on the Depressed rCBF and Brain Metabolism shortly after the Hypertensive ICH

Abstract

 The effect of perfluorodecalin and perfluorotripropylamine, Fluosol DA-20% (FDA-20%), on the ischemic brain after hypertensive intracerebral hemorrhage (ICH) was evaluated and the mechanism investigated. Regional cerebral blood flow (rCBF), and cerebral metabolic ratios of oxygen (CMRO₂) and glucose (CMRGlu) were measured before and after infusion of FDA-20%. The rCBF was estimated by single photon emission computed tomography using the ¹³³Xe inhalation method, and CMRO₂ and CMRGlu were determined by calculating arteriovenous difference between the femoral artery and the jugular bulb. The results showed: 1) The mean cerebral blood flow (mCBF) in both affected and non-affected hemispheres significantly increased by 10-20% over the control during 3 hours and 6-12 hours after infusion of 500 ml and 1000 ml FDA-20%, respectively. 2) Administration of 500 ml FDA-20% caused a maximal increase of 15% in CMRO₂ and 24% in CMRGlu, and 1000 ml FDA-20% administration caused a maximal increase of 30% in CMRO₂ and 75% in CMRGlu. 3) There was no significant change in mean blood pressure, arterial partial pressure of carbon dioxide and oxygen, or hematocrit before and after FDA-20% infusion. The results indicate that FDA-20% improved rCBF and brain metabolism in the ischemic brain of hypertensive ICH. FDA-20% may operate as an excellent oxygen carrier, and stimulate the brain metabolism directly.