Mn-Metalloporphyrin Conjugated with Gd-DTPA (Gd-ATN10): Tumor Enhancement Agent for Magnetic Resonance Imaging

Akira MATSUMURA; Yasushi SHIBATA; Tetsuya YAMAMOTO; Kunio NAKAGAWA; Susumu YASUDA; Susumu NAKAJIMA; Isao SAKATA; Takashi YOSHIZAWA; Tadao NOSE

doi:10.2176/nmc.37.327

Akira MATSUMURA, Yasushi SHIBATA, Tetsuya YAMAMOTO, Kunio NAKAGAWA, Susumu YASUDA, Susumu NAKAJIMA, Isao SAKATA, Takashi YOSHIZAWA, Tadao NOSE

Author information

Akira MATSUMURA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Yasushi SHIBATA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Tetsuya YAMAMOTO
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Kunio NAKAGAWA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Susumu YASUDA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Susumu NAKAJIMA
Department of Operative Surgery, Asahikawa Medical College
Isao SAKATA
Toyohakka Co. Ltd.
Takashi YOSHIZAWA
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
Tadao NOSE
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba

Keywords: gadolinium, metalloporphyrin, neutron capture therapy, magnetic resonance imaging, contrast enhancement

JOURNAL FREE ACCESS

1997 Volume 37 Issue 4 Pages 327-331

DOI https://doi.org/10.2176/nmc.37.327

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Abstract

A conjugate of manganese-metalloporphyrin and gadolinium (Gd)-diethylenetriaminepenta-acetic acid (Gd-ATN10) was developed as a tumor-specific enhancement agent for magnetic resonance (MR) imaging. Gd-ATN10 was evaluated in an experimental 9L gliosarcoma rat tumor model. T₁-weighted MR imaging showed enhancement of the tumor which persisted for up to 24 hours. Gd concentration measurement by inductively coupled plasma atomic emission spectroscopy revealed the peak Gd concentration was reached after 30 minutes and Gd was retained in the blood and tumor up to 24 hours. There was no uptake of Gd in the normal brain and little in the skin. Gd-porphyrin derivatives are potentially useful agents for tumor diagnosis on MR imaging and for neutron capture therapy.

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