Studies on the Syntheses and Antibiotic Action of Dehydroacyl acetic Acid and Dehydroacyl acetocarboxylic Acid

Part 1. Syntheses of Dehydroacylacetic acid and Dehydroacylacetocarboxylic acid

Abstract

(1) For the studies of antibiotic action, we sxnthesized several dehydroacylacetocarboxylic acids, among which dehydro-n-valeryl acetocarboxlic acid (m, p. 78_??_79°C), dehydro-isovalerylacetocarbo-itylic acid (m. p. 74°C) and dehydro-n-caproylacetocarboxyli_??_acid (M. P. 90_??_492°C) are new compounds.
(2) We also synthesized several dehydroacylacetic acids among which dehydro-n-valerylacetic acid (m. p. 44_??_45°C) dehydro-isovaleryladetic acid (b. p. I50_??_155°C/6mm.) end dehydro-n-caproyl acetid acid (m. p. 47_??_48°C) are new compounds.
(3) In the synthesis of dehydroacylacetocarboxylic acid from acetonedicarboxylic acid and acid chloride we obtained pure products in good yields by increasing the volume of sulfuric acid added. to acid chlorides or anhydrides as a catalyzer.