Studies on the Synthesis and Antibiotic Action of Dehydroabyl acetic acid and Dehydroacyl aceto carboxylic acid

Part 2. Antibiotic Action of Dehydroabyl acetic acid

Abstract

(1) On studying antibiotic action of dehydroacetic acid (I) and dehydrobutyrylacetic acid (II) against several microorganisms, we found these compounds have antibiotic activitities on yeasts and molds such as Saccharomyces, Zygosaccharomyces, Pichia, Penieillium, Aspergillus and Rhizopus; but not so strong on Lactobacillus and Acetobacter.
(2) (I) inhibited the growth of those molds at 1:10, 000, and yeasts at 1:5, 000; (II) at 1:50, 000 and 1:30, 000, respectively.
(3) (II) showed stronger activity than p-oxybenzoic acid butyl ester in antibiotic test on the pellicle-forming yeast of soy sauce.