Studies on the Invert Soap as the Fungicide. Part 1

Abstract

We have synthesized the following quaternary ammonium compounds. (1-a) dimethyl-octyl-benzyl ammonium chloride, mp. 74°, plates ; (1-b) dimethyl-dodecyl-benzyl ammonium chloride, mp. 45°, scales; (1-c) dimethyl-hexadecyl-benzyl ammonium chloride, mp. 55_??_6°, needles; (1-d) dimethyl-octadecyl-benzyl ammonium chloride, mp. 150_??_8°, scales; (2) dimethyl-dodecyl-methylthioethyl ammonium. chloride, mp. 59°, plates; (3) N, N'-bisdimethyl-N, N, N'-bisdodecyl-(N-ethyl-thio-N'-ethyl)-diammonium chloride, mp. 209°, scales; (4) dimethyldodecyl-phenylthi-oethyl ammonium chloride, mp. 82.5°, needles; (5) nicotine-N, N'-bisdodecyl chloride, mp. 99°, scales.
We have examined their germicidal activities using the spores of Gibberella Fujikurol as testing microorganism and compared with that of a 10^-3 solution of Uspulum (Uspulum contains 3% of methoxyethyl mercuric chloride and, therefore, the concentration of this Uspulum solution corresponds to a 3×10^-4 solution of methoxyethyl mercuric chloride). The figures in the following table indicate the dilution of synthesized compounds which shows the same physiological activity as that of a 10^-3 solution of Uspulum.
(1-a) 100 (1-c) 160.000 (2) 10.000 (4) 220.000
(1-b) 800.000 (1-d) 120.000 (3) 80.000 (5) 4.000