On the Blinding Activities and Acute Oral Toxicities of Aminbenzenes, Phrimidines, Purines, Amino-s-Triazines and Their Related Compounds in Baby Chicks

Abstract

Feeding experiments were carried out on male baby chicks of Goto-606 and Goto-607 strains with several aminobenzenes. pyrimidines, purines, amino-s-triazines and their related compounds.
When the chemical contents in feeds were 1 and 3%, blindness did not occur in baby chicks except after administration of formoguanamine and 2-amino-s-triazine. One of three chicks given feeds containing 3% 2, 4-bis (acetylamino)-s-trizaine showed discolouration of the retina. Introduction of the N-substituted amino group (s) into formoguanamine and 2-amino-s-triazine die not cause blindness in chicks.
When phenylenediamines were given to chicks orally (1% active ingredients), they showed acute toxicities. Amino-dichloro-s-triazines (1% a. i.) showed the strongest lethal toxicity among four types of amino-s-triazines. But most heterocyclic compounds without s-triazines did not show any toxicity.
2, 4-Bis (diethylamino)-s-triazine and 2-ethylamino-4-isopropylamino-s-triazine (3% a. i.) did not cause blindness but caused loss of appetite in baby chicks.