Simultaneous Determination of Carbamates in Formulations by High Performance Liquid Chromatography

Abstract

A high performance liquid chromatographic method was developed for determination of seven carbamates: 2-sec-butylphenyl N-methylcarbamate (BPMC), 4-dimethylamino-3-methylphenyl N-methylcarbamate (aminocarb), 2-(1-methylethoxy)-phenyl N-methylcarboxylate (arprocarb), m-tolyl N-methylcarbamate (MTMC), 1-naphthyl N-methylcarbamate (carbaryl), 3, 4-xylyl N-methylcarbamate (MPMC) and 3, 5-xylyl N-methylcarbamate (XMC), in formulations. These carbamates were separated from one another and determined simultaneously within 22 minutes under the following chromatographic conditions: column, stainless steel (4mmφ×30cm) packed with μBondapak CN (10μm); mobile phase, hexane-ethyl acetate (25+1); flow rate, 1.0ml/min; detector, UV photometer at 254nm. The recoveries of carbamates from oil, EC, powder, dust and aerosol formulations were 97 to 101% with a 0.7% coefficient of variation.