Successful Management of a Patient with Multiple Nucleos(t)ide Analogue-Resistant Hepatitis B Virus and Diffuse Large B Cell Lymphoma Using Tenofovir Disoproxil Fumarate: A Case Report

Mizutani Taku; Matsuoka Shunichi; Kikuta Daiichirou; Hayama Jou; Nagai Shintaro; Matsumoto Naoki; Nakamura Hitomi; Nirei Kazushige; Kanda Tatsuo; Moriyama Mitsuhiko; Miura Katsuhiro; Takei Masami; Sugitani Masahiko

doi:10.4264/numa.78.5_295

症例報告

Successful Management of a Patient with Multiple Nucleos(t)ide Analogue-Resistant Hepatitis B Virus and Diffuse Large B Cell Lymphoma Using Tenofovir Disoproxil Fumarate: A Case Report

Mizutani Taku, Matsuoka Shunichi, Kikuta Daiichirou, Hayama Jou, Nagai Shintaro, Matsumoto Naoki, Nakamura Hitomi, Nirei Kazushige, Kanda Tatsuo, Moriyama Mitsuhiko, Miura Katsuhiro, Takei Masami, Sugitani Masahiko

著者情報

Mizutani Taku [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Matsuoka Shunichi [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Kikuta Daiichirou [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Hayama Jou [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Nagai Shintaro [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Matsumoto Naoki [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Nakamura Hitomi [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Nirei Kazushige [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Kanda Tatsuo [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Moriyama Mitsuhiko [日本]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Miura Katsuhiro [日本]
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Takei Masami [日本]
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [日本]
Sugitani Masahiko [日本]
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan [日本]

キーワード: chronic hepatitis B, multiple drug resistance, rituximab, lymphoma, tenofovir disoproxil fumarate

ジャーナルフリー

2019 年 78 巻 5 号 p. 295-300

DOI https://doi.org/10.4264/numa.78.5_295

詳細

抄録

Background: Malignant lymphoma is occasionally observed in chronic hepatitis B virus (HBV)-infected patients. The occurrence of HBV reactivation or acute exacerbation of chronic hepatitis B during and after chemotherapy and immunosuppressive therapies is a major issue. Case presentation: We reported a 65-year-old Japanese man with multiple nucleos(t)ide analogue (NUC)- resistant HBV infection and diffuse large B cell lymphoma (DLBCL), stage IV. The patient was treated with the addition of tenofovir disoproxil fumarate to entecavir and chemotherapy to control the HBV and treatment of lymphoma, respectively. Both diseases were safely controlled. Conclusion: Clinicians should pay careful attention to NUC-resistant HBV and select the proper NUCs to control the virus before and during the commencement of chemotherapy.

責任著者(Corresponding author)

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