Original Articles
In vivo Assessment of Tissue Compatibility of Root Canal Sealer Containing Surface Pre-reacted Glass-ionomer Fillers
2022 年 2 巻 1 号 p. 33-39
詳細
2022 年 2 巻 1 号 p. 33-39
Purpose: Surface pre-reacted glass-ionomer (S-PRG) fillers possess properties of releasing ions such as fluoride, strontium, and borate ions, and exhibit bioactive effects. In this study, we assessed the in vivo preclinical effect of a sealer containing S-PRG filler (S-PRG sealer). Specifically, we evaluated the inflammatory response of periapical tissues to the use of S-PRG sealer in root filling, compared to that of sealers with other main components (mineral trioxide aggregate (MTA), resin, and noneugenol-zinc oxide (ZO) ).
Materials and Methods: Under general and local anesthesia, premolar pulpectomies were performed in 10-month-old beagle dogs. After root canal preparation, cleaning, and drying, root filling was performed by applying various sealers with gutta-percha master points. Periapical lucency was analyzed radiographically, and the area of inflammatory cell infiltration with bone resorption was analyzed histologically. The inflammatory response of periapical tissues to S-PRG sealer was compared to those of clinically used sealers including MTA (Pro Root MTA), resin (AH Plus), and ZO (Canals N). Tissue specimens were prepared at 1 month and 6 months after obturation.
Results: Periapical lucency was observed at 1 month in all groups. However, at 6 months, periapical lucency persisted with Canals N, but was infrequent with the other three fillers. In histological sections at 1 month, all groups showed similar levels of infiltration of inflammatory cells into the periodontal tissues adjacent to the root apical foramen. After 6 months, inflammation of the periodontal tissues was significantly improved (p<0.05) for all sealers except for Canals N.
Conclusion: The inflammatory response to S-PRG sealer at periapical tissues was milder than that to Canals N. The S-PRG sealer may provide biocompatibility comparable with that of commonly and clinically used Pro Root MTA and AH Plus in the healing of the periapical region.
