抄録
Differences in the ultrastructure between periportal and centrilobular hepatocytes were studied quantitatively for newborn,5-day-old,10-day-old and adult mice. In newborn animals there were no differences between periportal and centrilobular cells in the area and number (per unit area of the cytoplasm in crosssection)of the mitochondria, smooth endoplasmic reticulum, rough endoplasmic reticulum, lysosomes, peroxisomes and lipid droplets, and in the shape of the mitochondria. In 5- and 10-day-old animals, however, differences were seen in the area of the mitochondria and smooth endoplasmic reticulum, and in the shape of the mitochondria. Adult hepatocytes show additional differences in the number of the mitochondria and peroxisomes, and in the area and number of the lysosomes. Thus, in general, the ultrastructural heterogeneity among hepatocytes, evident in adult animals, is not present in newborn animals but appears during postnatal development.
