抄録
Acute encephalomyelitis following vaccination and measles is representative of secondary encephalomyelitides which appear after acute general infection. In their pathomorphology focal proliferation of microglia and histiocyte around the vene Predominates in the whole central nervous system together with scarse lympho-histiocytic perivenous cuffs. Myelin sheath is also vulnerable within the lesion.
Based on the characteristics of these pathological changes, secondary encephalomyelitides have been considered as caused by an abnormal immune response allergic reaction of the host, to the primary infection. This concept seems to be supported by the facts that the same lesion can be evoked irrespective of a variety of causative agents without success in recovery of infective virus from nervous tissue of the patient, and that experimental allergic encephalomyelitis has pathological features almost similar to those of secondary encephalomyelitis
Recent research progress on etiopathogenesis of subacute sclerosing panencephalitis clearly indicates that merely morphological identification of various pathological conditions should be made cautiously. Aneffort of further investigation would be required from virological view point.
