L-DOPAが奏効したDystoniaの1例

抄録

A child case with idiopathic dystonia is presented, who has shown remarkable improvement for twelve months by L-DOPA administration. This Japanese girl, six years and one month old, had been completely healthy until the age of five, when gait disturbance appeared, which gradually increased. On examination in Dec. 1970 she presented marked difficulty in gait with tremor of arms, plantar flexion-inversion of feet, dynamic dystonic posture with rigidity and lumbar lordosis. The level of serum ceruloplasmin was normal. PEG, CAG, EEG and fundoscopic examination revealed no abnorm alities. Three months after admission, her gait became more deteriorated and L-DOPA treatment started, with inital dosage of 100 mg daily and gradually increasing up to 300mg. Seven days after 300mg of L-DOPA administration, gait disturbance and dynamic dystonia were remarkably improved. She has been under continued medication of L-DOPA for about twelve months till present and maint enance dose is now 400 mgdaily and she is in quite satisfactorily good condition.