Transdermal Delivery of Macromolecule and Nanoparticles via Faint Electricity

Abstract

Iontophoresis (IP) is a noninvasive technology that physically enhances transdermal penetration of ionic medicines using faint electricity. IP was generally considered to be effective only for charged amphiphilic small molecules. However, in vivo iontophoretic transdermal delivery of various macromolecules was recently successfully achieved. Moreover, skin physiology is changed by faint electricity. Here, we summarize the recent topic regarding transdermal delivery of macromolecules and nanoparticles by faint electricity.