2017 Volume 17 Issue 8 Pages 349-357
Self-setting apatite bone cement is consists of metastable calcium phosphates, and was transformed to the low-crystallinity apatite with bioaffinity to natural bones. Various drugs were kneaded in the cements to prepare a drug sustained-release artificial bone cement. Since the in vitro drug release rate from the apatite bone cements followed Higuchi equation, it was possible to control drug release by the parameters, such as drug concentration, porosity, granular diameter and diffusion coefficient. On the other hand, the result of in vitro and in vivo drug release suggested that in vivo drug release from the apatite cement devices was depended on calcium concentration in a body fluid. The results indicated that apatite bone cement containing drugs was transformed into low crystalline apatite with high affinity for bone, so the degree of osteoporosis responsive drug release from artificial bone could be create based on this high functional bone cement. Furthermore, osteoporotic drugs were applied to apatite-collagen composite cement to prepare three-dimensionally perforated macroporous bone cell scaffold. This highly functional artificial bone was shown to be suitable for bone regeneration.
