Development of Phospholipase for Unevenly Distributed Phospholipids Determination

Abstract

The cell membranes of cells existing on the earth utilizes phospholipids as the main component without exception. This seemingly universal phospholipids have a significantly different structure and composition depending on the species, tissue, organelle, etc., and is unevenly distributed. In recent years, ether-type phospholipids, which are unevenly distributed in humans, have attracted a great deal of attention as biomarkers for early detection of serious diseases, and are being actively studied. In this review, we will describe the discovery of several novel phospholipases that act specifically on unevenly distributed phospholipids and efforts toward its application.