Oral Medicine & Pathology
Online ISSN : 1882-1537
Print ISSN : 1342-0984
ISSN-L : 1342-0984
Original
Ultrastructural and Immunocytochemical Characterization of the Bone-Single Crystal Sapphire Implant Interface in the Rat Maxilla
Joviniano Martins de Oliveira JrTetsuji OgawaHiroyuki KawaguchiYuri FujitaniTeruko FujiwaraKeiji NakanishiTomie HigashiHidemi Kurihara
著者情報
ジャーナル フリー

1996 年 1 巻 2 号 p. 84-89

詳細
抄録
To evaluate the suitability of a new implant animal model, we examined the host response to single crystal sapphire implant into the rat maxilla socket and characterized the regenerating tissue-implant interface using a combination of morphological and immunocytochemical approaches. At 2, 4, and 8 weeks after implantation, animals were sacrificed and tissues processed for morphological or immunocytochemical studies. Results demonstrated that nonmineralized connective tissue was present between bone and the implant surface. However, in some situations at 8 weeks, direct bone contact was observed. Electron microscopy revealed that the interface between the implant and the regenerating tissues was characterized by the presence of either cells or an intervening extracellular matrix layer that had a variable appearance and thickness.The bone-implant interface was immunoreactive for osteopontin. The rat maxilla socket implant model, due to its ease of management and its similarities to other previous experimental animal models, seems to be useful for some specific implant experimental studies.
著者関連情報
© 1996 The Japanese Society of Oral Pathology
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