日本温泉気候学会雑誌
Online ISSN : 1884-3689
Print ISSN : 0369-4240
ISSN-L : 0369-4240
酸性泉 (玉川温泉) 浴湯の生体に及ぼす影響の血清学的研究
酸性泉 (玉川温泉) 浴湯皮膚炎に於ける皮膚炎皮膚組織成分の自家抗原性に就いて
遠藤 英武
著者情報
ジャーナル フリー

1955 年 19 巻 2 号 p. 69-121

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抄録
1. Experimentation on Human Body; Especially the Identification of Antigen and Antibody in the Bathers.
1) Clinical Observation of the Bathing Dermatitis in Tamagawa Hot Spring.
The incidence of dermatitis is influenced by the frequency of bathing. In case of bathing 2 to 3 times a day, it appears between the 5th and 10th day, and in case of 4 to 7 times, it appears between the 1st and 5th day. It intensifies within a week and declines afterwards. It is liable to appear at the front, upper chest, neck and nucha, also at the private parts and the armpit where it is easy to form erosion. Redding is seen in all cases and papules also in many cases, but almost no feeling of itch is complained of subjectively, but merely the feeling of smart in case of bathing.
According to Toriyama of the Department of Dermatology, Tohoka University, it is characteristic that these are almost no changes in the epidermis, but remarkable changes in the papillary and subpapillary layers, such as the extension of blood vessels filled with blood corpuscles, perivascular edema and cell infiltration, mostly round cell infiltration, and a considerable number of polynuclear, nentrophiles, the edema of connective tissue which appears foremost between fibers with the low stainahility of the nucleus of many fibrocytes that seem to be edematous, and to contain some histiocytes. Moreover he presumes that the stimulating substance, probably hydrochloric acid, penetrates to the corium through the sebaceous duct or sudoriferous duct and produces the main changes in the papillary and subpapillary layers causing this peculiar dermatitis.
2) Identification of Mb Antibody in the Serum of Bathers affected with Bathing Dermatitis in Tamagawa Hot Spring.
In carrying out the precipitation on the serum of bathers affected with the bathing dermatitis, using the Mb solution of human heart as the antigen, Mb antibody with values of 20 times 2 to 100 times 8 in the bathers with marked dermatitis, that with 20 times 1 to 50 times 1 value in bathers with slight dermatitis, and that of negative value in the control people who did not take a bath, was noticed. Moreover the Hb anitibody was completely negative in bathers with dermatitis. Thus it seemed that the denaturalized Mb is produced at the parts affected with bathing dermatitis in Tainagawa Hot Spring and activates the ground of antibody production to generate the Mb antibody after it is absorbed.
3) Relationship between the Manifestations of Bathing Dermatitis in Tamagawa Hot Spring and the Mb Antibody in the Serum of Bathers.
For example, after bathing 2 to 4 times a day the dermatitis broke out at the 4th day, the Mb antibody appeared on the next day; during 8 days with such bathing this antibody was positive; the dermatitis was present till the 8th day after suspension of bathing; the Mb antibody was still positive on the 4th day after the disappearance of dermatitis, but became negative on the 10th day. Thus the production of Mb antibody was observed shortly after the appearance of dermatitis, and the autoantibody disappeared during a period of one to two weeks after the subsidence of dermatitis.
4) Relathionship between the Course of Bathing Dermatitis and the Precipitation between the Self-Urine and-Serum.
It is easy to presume that in base of the outbreak of dermatitis the denatruralized tissue substance at that locality might appear in the urine after it is absorbed, Assuming the urine as the antigen to attempt its precipitation with serum, the value turned positive in the reaction between the urine of the 2nd day after the outbreak of dermatitis and the serum of the next day, stayed positive till the reaction between the urine of the 4th day after the subsidence of dermatitis and the serum of the next day, and then turned negative from thereon. Thus it is recognized that the denaturalized tissue substance produced at the locality of dermatitis is excreted into the blood stream and subsequ
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