動物実験モデルによる心停止ドナーからの肺移植の経験と臨床応用への可能性
2012 年 19 巻 1 号 p. 76-79
詳細
2012 年 19 巻 1 号 p. 76-79
Brain-dead donors and living lower lobe donors are utilized for clinical lung transplantation in Japan. But it is limited by the availability of the donors because of medical and cultural hurdles. To expand the donor source, we performed lung transplantation from non-heart beating(NHB)donors after brain death in animal experimental models in the 1990s. We succeeded left lung transplantation from NHB donor in a canine model and bilateral lung transplantation from NHB donor in a primate model. It is concluded that the NHB donor after brain death is available for lung transplantation but some medical, social and cultural issues should be still resolved to utilize NHB donors for clinical lung transplantation in Japan.
