ジヒドロストレプトマイシンの内耳神経侵襲の予防的効果に就ての実験的研究

抄録

Intrathecal administration of DHSM to guinea pigs resulted in the death of a majority of the animals. However, concomittant intramuscular injections of vitamin A or B₁ decreased the death rate of the experimental animals, especially when both vitamins were administered.
It was also confirmed histopathologically that the combined intramuscular use of vitamins A and B1 is useful in preventing to a certain extent damages in the acoustic organ caused by DHSM.
In animals receiving intramuscular administration of DHSM combined with intrathecal injection of vitamin B₁, the grade of damage in the acoustic organ was less significant than when only intramuscular injection of DHSM was given.
As the result of these findings, it is considered that the intrathecal use of vitamin B₁ is of value in preventing to some extent damages in the acoustic organ ca used by DHSM.