口腔Candida症の臨床的観察とその実験的研究

抄録

In 22 cases of oral candidiasis encountered at the Otorhinolaryngeal Department of Tokyo Jikeikai School of Medicine, clinical and experimental investigations have been carried out.
In general, oral ulcers due to candidiasis show various forms and courses. In particular, a major characteristic of these ulcers is their frequent recurrences from one form and type to another.
No untreated dental caries were found in the 22 patients. Four of them had completely sound teeth and the others had artificial dentures or gold, siver alloy or sanplatina crown fixtures. There is no known remedy for satisfactory control of this disease. However, it is considered that potassium iodide and Tricomycin might be useful in large dosage.
The pH of the saliva in these patients shows a tendency towards the alkaline side and in vitro tests with Candiada isolated from the ulcers reveal maximum growth at pH 7.5. Accordingly, the clinical observation that oral candidiasis was encountered only in patients with no dental caries in this study may be noteworthy.
Blood sugar tests in the 22 patients did not reveal any specific findings. Althoug the isolated strains of Candida grew in test tubes at any concentration of glucose, the optimum percentage for growth appeared to be 2%.
Examination of the function of the autonomic nervous system in these patients with Wenger's test shows a slight tenency of sympathicotomia. Of course, further investigation is required but it might be surmised that this clinical observation could be an important causal factor in this disease.