頭頸部悪性腫瘍に対する動注療法時の舌乳頭血管変化について

抄録

Since 1963 the authors used intra-arterial infusion of anti-cancer drugs as preoperative treatment for head and neck malignancies. The authors observed in many cases that steady retraction of tumors was arrested after a certain doses of the infusion.
The authors studied local blood vessels finding significant changes after the arterial infusion of certain doses, which might have been one of the causes of the observed inefficiency in the treatment.
They observed blood vessels in the lingual papillae by means of Ultropak and found marked changes of the arterioles after arterial infusion of Bleomycin. Such changes of the blood vessels often accompanied by stomatitis.
The authors suggested that these changes of the blood vessel could be prevented by simultaneous infusion of reduced glutathione (GSH).