実験的中耳炎における杯細胞に関する研究

抄録

It is known that middle ear mucosa has a characteristic with secretory function as a respiratory epithelium, and secretory cell also exists very slightly in the normal middle ear mucosa. In recent years, it is reported that increasing tendency of it has been noted, and by its pathohistological finding of the otitis media with effusion being studied about its etiology and morphology, goblet cell increases to 20-100 times compared with that of normal con dition. In this study, conditions of the goblet cell in the middle ear mucosa added various procedures for rabbits were observed, and its increasing factor was discussed and reported as follows.
With regard to the experimental method, rabbits were bred proceduring close of tympanic orifice of the eustachian tube, close of pharyngeal orifice of the eustachian tube, stenosis of tympanic isthmus and stimulation of external auditory meatus, and subsequently they were sacrificed. A mass of osteoblast of middle ear and external meatus was extirpated, and increasing degree of the goblet cell in its middle ear mucosa, edema, condition of inflammatory cell infiltration, and presence or absence of tympanic perforation were observed. From the result, the increase of goblet cell was noted in 36.7%, 18.3%, 16.3%, 33.9%, and 25.8% of cases with close of tympanic orifice of the eustachian tube, close of pharyngeal orifice of the eustachian tube, stenosis of tympanic isthmus, opening of the external auditory meatus stimulated the external auditory meatus, and close of the external auditory meatus stimulated the external auditory meatus, respectively. The frequency of the tympanic perforation in the increaing case of goblet cell was noted in 68.2%, 54.5%, 42.9%, 100% and 93.4% of cases with close of tympanic orifice of the eustachian tube, close of pharyngeal orifice of the eustachian tube, stenosis of tympanic isthmus, opening of the external auditory meatus stimulated external auditory meatus, and close of external auditory meatus stimulated external auditory meatus, respectively, and goblet cell increased in infectious cases associated with ympanic perforation. Moreover, in the increasing cases of goblet cell, inflammatory cell infiltration on the subepithelium was noted in all cases, and the higher its degree is, the higher the decreasing degree of goblet cell became. The increase of goblet cell was remarkably noted in marked cases of the inflammatory cell infiltration in mainly lymphocyte, and somewhat relationship between change of the epithelium and condition of the subepithelium was estimated. It has been reported so far that the infection is considerably concerned for the increase of secretory cell, and from this experimental result, it is presumed that the infection concerned for the increase of goblet cell in the middle ear mucosa.