ヒスタミン遊離抑制におけるヒスタミンレセプターの役割

スギ花粉症患者白血球でのH₁及びH₂刺激剤による実験

抄録

The histamine release from the leukocytes of Sugi Pollinosis patients is inhibited by histamine itself.
We examined whether the histamine-induced inhibition of histamine release was brought about by the stimulation of H₁ or H₂ receptors. 2-methylhistarhine as the H₁ agonist and 4-methylhistamine as the H₂ agonist were used.
The results are as follows.
1. The percent inhibition of the histamine release due to antigen stimulation by histamine was 69.2±20.5%(mean±SD), and by H₁ agonist was 28.0±20.1%, by H₂ agonist was 56.1±22.4%,
2. This inhibition was significantly higher in the antigen-induced release than in the natural release.
3. The inhibition effects of H₁ agonist against per histamine was 39.2±25.5% and of H₂ agonist was 80.4±19.0%.
4. The feedback mechamism of histamine release is almost found upon the stimulation of the H₂ receptors, but only in a little part is found upon the stimulation of the H₁ receptors.