リノセルム使用が鼻粘膜形態並びにその透過性に与える影響に関する研究
1988 年 31 巻 Supplement5 号 p. 483-488
詳細
1988 年 31 巻 Supplement5 号 p. 483-488
The influence of “Rhinotherrn ®” (humidified hot air ((43 °C)) insufflator for the nasal passages) on natal mucosa was evaluated functionally and morphologically.
After 30 minutes, 2 hours and 4 hours insufflations to the nose, 40 mg of hoarseradish peroxidase (HRP, Sigma tipe vi: 0.5 mg per ml, in saline) was inhaled into the guinea pigs' nasal passage with a nebulizer. Then septal mucosa was removed and observed under a light microscope and an electron microscope (Hitachi H-600).
The present study indicates neither permeability enhancement of the nasal mucosa nor the morphological changes of the cell membranes The organella showed no changes after “Rhinotherm ®” insufflation.
Therefore, it can be concluded that “Rhinotherm ®” is not harmful to the nasal mucosa if it is used correctly.
