Abstract
Roxithromycin (RXM 150-300mg/day) and Keigai-Rengyo-To (Tsumura TJ-50 7.5g/day) were administered concurrently for a period of four to eleven weeks in 12 cases of adult patients with chronic sinusitis during acute exacerbation. CT was employed for an objective judgement of the results of the treatment.
1. Clinical observations showed that this treatment was efficient in 2 cases and very efficient in 10 cases, and in these latter cases, all of the subjective symptoms disappeared in 2 to 6 weeks after the initiation of treatment. In the efficient cases, only acute exacerbationdisappeared.
2. In the 10 cases where the treatment was very efficient, the cure was confirmed in one case by an operation. In the remaining nine cases, a comparison of CT findings obtained before and after the treatment confirmed the disappearance of the uniform abnormal findings, such as shadows, thickening of the mucus membrane, and formation of liquid on the surface, in the maxillary and ethmoidal sinuses. There was no change in the CT findings obtained from the twoefficient cases.
3. Compared with the previous sole administration of EM antibiotics or TJ-50, there was a marked reduction in the period required with the concurrent administration of RXM and TJ-50, and we considered that the effect of the treatment was complete.
