Abstract
Nebulization Therapy as a topical treatment for sinusitis is one of the most widely used therapies because of its safety and convenience. We investigated surface and tissue transitional concentration of aerosol of antibacterial agents in treatment of the nasal cavity and paranasal sinusitis via a ultrasonic-type or a jet-type nebulizer, and we reported that nebulization therapy with antibacterial agents was valuable for improvement of middle meatal pathology and brought on sufficient transitional concentration of agents to the maxillary sinus. However, clinical evaluations of nasal nebulization therapy have not been standardized, we are anticipating the establishment of a grading standard for clinical efficacy.
In the present study, we attempted to establish a simple grading standard for the clinical efficacy of nasal nebulization therapy. We indicated the grading standard for subjective and objective symptoms during clinical trials of new drugs, and the results of clinical evaluation according to this grading standard. We indicated the simple grading standard of clinical efficacy consisting of 6 observation items (subjective symptoms : headache, nasal discharge, nasal obstruction ; objective symptoms : amount of nasal discharge, swelling of nasal mucosa, character of nasal discharge). These assessments require professional knowledge and judgment in the otolaryngological field. Nasal nebulization therapy as well as upper respiratory tract nebulization therapy should be performed under the supervision and direction of an otolaryngologist.
