Abstract
Ultrasonic nebulization is widely performed for inhalant therapy. But there still remain some ploblems in the stability of the drug in inhalant solutions during ultrasonic nebulization. We have reported that the remaining ratios of some drugs were below 90% after nebulization using the conventional ultrasonic nebulizer. The drugs that showed a decrease in content, a change in appearance or produce a bad smell after ultrasonic nebulization should be used carefully. And it is necessary to develop a special preparations for nebulizaton therapy.
A new ultrasonic nebulizer has been developed by OMRON. We investigated the effect of the new ultrasonic nebulizer on the stability of some drugs for inhalant therapy. Stability tests were performed on drugs in terms of visible changes, pH, smell and degradation rate of the drug after ultrasonic nebulization. The changes in pH, apparent appearance and smell were not observed for the drugs. The ratios of all drugs remained at more than 95% after ultrasonic nebulization using the new ultrasonic nebulizer.
Therefore, the drugs are highly stable using new ultrasonic nebulizer and should be effective. We concluded that the new ultrasonic nebulizing method can be applied in the inhalant therapy of many inhalant preparations.
