Cisplatin投与後の内耳感覚上皮細胞の変化
1982 年 13 巻 1 号 p. 130-131
詳細
1982 年 13 巻 1 号 p. 130-131
Guinea pigs were administered 12.5mg/kg of cisplatin intravenously and sacrificed 1-7 days lates. The ultrastructural changes of the cochlear hair cell, utricular sensory cell and dark cell were reported. At 4 days after the injection, the outer hair cells were began to degenerated but the inner hair cells were almost normal. At 7 day after the injection, the endolymphatic space was collapsed. In the utricular sensory cells type I, a few of degenerated sensory cells type I were observed at 7 days after the injection. In dark cell at 7 days after the injection, a few vacuoles were found.
