数種の聴器毒による蝸牛病態, とくにラセン器病変の比較検討

抄録

There are a number of drugs and chemicals which affect the inner ear to create temporary or permanent morphological alterations in auditory or vestibular systems. However, its true etiological mechanism or more detailed pathogenesis to manifest toxic effect on the inner ear following administration of these substances has still remained obscure, even when the aminoglycoside antibiotics that have been extensively used so far were given to human subjects or experimental animals. Furthermore, it has been known that there are considerable variations in the inner ear pathology from one to another depending on the ototoxic substances.
It is the purpose of this paper to present several histopathological findings appeared in the organ of Corti of the guinea pig cochleae using various ototoxic drugs and chemicals and, by comparing with these findings, to discuss any possible explanations to interprete these morphological changes found in the organ of Corti of the cochleae. The drugs and chemicals with ototoxic effect on the organ of Corti used in this experimental study were: nitromin, hybrimycin (A & B), bromates and cisplatin.